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XU Leping, JI Juying, DUAN Yiyang, SHI Hui, ZHANG Bin, SHAO Yaqin, SUN Jian
《医学前沿(英文)》 2007年 第1卷 第3期 页码 316-319 doi: 10.1007/s11684-007-0061-z
关键词: significant difference occurrence hemoglobin risperidone treatment abnormal
The
Prayoga SURYADARMA, Yoshihiro OJIMA, Yuto FUKUDA, Naohiro AKAMATSU, Masahito TAYA
《化学科学与工程前沿(英文)》 2012年 第6卷 第2期 页码 152-157 doi: 10.1007/s11705-012-1287-0
关键词:
Anti-biofouling strategies for implantable biosensors of continuous glucose monitoring systems
《化学科学与工程前沿(英文)》 2023年 第17卷 第12期 页码 1866-1878 doi: 10.1007/s11705-023-2340-x
关键词: implantable glucose biosensor anti-biofouling continuous glucose monitoring immune responses
中药生物活性成分对糖脂代谢紊乱疾病的治疗作用和机制 Review
张莹, 鞠佳明, 焦磊, 杨宝峰
《工程(英文)》 2023年 第29卷 第10期 页码 73-82 doi: 10.1016/j.eng.2023.03.004
胆固醇和葡萄糖稳态异常在心血管疾病、脑血管疾病、中枢神经系统疾病和癌症等多种疾病的发生发展中起着至关重要的作用。 越来越多的研究表明,体内脂肪堆积过多与2型糖尿病或胰岛素抵抗有关,高胆固醇和高血糖将加重上述疾病的发展进程。因此,稳定患者的血脂和血糖水平是改善心脑血管和中枢神经系统疾病患者症状的主要策略。中药(CHM)在中国已有两千多年的历史,建立了独特的中医理论,积累了丰富的临床经验。此外,中药在国内外广泛应用于心脑血管疾病的治疗和预防,具有防治高脂血症、糖尿病和高血压等疾病的优势。然而,中药在西方国家的使用仍然相当有限,部分原因是对其多种复杂成分的了解不完整,药理机制不确定。本文就中药生物活性成分及其制剂治疗高脂血症和高血糖症的作用、分子机制和临床研究进展进行综述和讨论。
关键词: Chinese herbal medicines Hyperlipidemia Hyperglycemia Cardiovascular and cerebrovascular diseases
《医学前沿(英文)》 2023年 第17卷 第1期 页码 68-74 doi: 10.1007/s11684-022-0955-9
关键词: complexity of glucose time series continuous glucose monitoring impaired glucose regulation insulin secretion and sensitivity refined composite multi-scale entropy
《化学科学与工程前沿(英文)》 2023年 第17卷 第10期 页码 1593-1607 doi: 10.1007/s11705-023-2348-2
关键词: cellulose nanofibril aerogel nickel-cobalt layered double hydroxide polypyrrole nonenzymatic glucose sensor
Clinical laboratory features of Meigs’ syndrome: a retrospective study from 2009 to 2018
Wenwen Shang, Lei Wu, Rui Xu, Xian Chen, Shasha Yao, Peijun Huang, Fang Wang
《医学前沿(英文)》 2021年 第15卷 第1期 页码 116-124 doi: 10.1007/s11684-019-0732-6
关键词: Meigs’ syndrome ovarian thecoma-fibroma NLR (neutrophil to lymphocyte ratio) CD4+ T cells glucose metabolism
Proteins moonlighting in tumor metabolism and epigenetics
Lei Lv, Qunying Lei
《医学前沿(英文)》 2021年 第15卷 第3期 页码 383-403 doi: 10.1007/s11684-020-0818-1
《医学前沿(英文)》 2021年 第15卷 第3期 页码 460-471 doi: 10.1007/s11684-021-0861-6
关键词: low-carbohydrate diet obesity nonalcoholic fatty liver disease continuous glucose monitoring mean sensor glucose
null
《医学前沿(英文)》 2018年 第12卷 第3期 页码 307-318 doi: 10.1007/s11684-017-0547-2
Acute ischemic stroke (AIS), as the third leading cause of death worldwide, is characterized by its high incidence, mortality rate, high incurred disability rate, and frequent reoccurrence. The neuroprotective effects of extract (GBE) against several cerebral diseases have been reported in previous studies, but the underlying mechanisms of action are still unclear. Using a novel rat cortical capillary endothelial cell-astrocyte-neuron network model, we investigated the neuroprotective effects of GBE and one of its important constituents, Ginkgolide B (GB), against oxygen–glucose deprivation/reoxygenation and glucose (OGD/R) injury. In this model, rat cortical capillary endothelial cells, astrocytes, and neurons were cocultured so that they could be synchronously observed in the same system. Pretreatment with GBE or GB increased the neuron cell viability, ameliorated cell injury, and inhibited the cell apoptotic rate through Bax and Bcl-2 expression regulation after OGD/R injury. Furthermore, GBE or GB pretreatment enhanced the transendothelial electrical resistance of capillary endothelial monolayers, reduced the endothelial permeability coefficients for sodium fluorescein (Na-F), and increased the expression levels of tight junction proteins, namely, ZO-1 and occludin, in endothelial cells. Results demonstrated the preventive effects of GBE on neuronal cell death and enhancement of the function of brain capillary endothelial monolayers after OGD/R injury ; thus, GBE could be used as an effective neuroprotective agent for AIS/reperfusion, with GB as one of its significant constituents.
关键词: acute ischemic stroke Ginkgo bilobaextract Ginkgolide B network model neuroprotection
Hui Wang, Yang Zhang, Zhujun Shen, Ligang Fang, Zhenyu Liu, Shuyang Zhang
《医学前沿(英文)》 2021年 第15卷 第1期 页码 70-78 doi: 10.1007/s11684-020-0749-x
关键词: myocardial infarction percutaneous coronary intervention diabetes mellitus fasting glucose heart failure
null
《医学前沿(英文)》 2014年 第8卷 第4期 页码 477-483 doi: 10.1007/s11684-014-0346-y
The association between dyslipidemia and elevated fasting glucose in type 2 diabetes is well known. In non-diabetes, whether this association still exists, and whether dyslipidemia is an independent risk factor for high fasting plasma glucose (FPG) levels are not clear. This cross-sectional study recruited 3460 non-diabetic Chinese subjects (1027 men, and 2433 women, aged 35–75 years old) who participated in a health survey. Men and women were classified into tertiles by levels of plasma lipids respectively. In women, the prevalence of impaired fasting glucose (IFG) was decreased with increased HDL-C. A stepwise increase in HDL-C was associated with decreasing FPG levels (lowest tertiles, FPG: 5.376±0.018; middle tertiles, 5.324±0.018; highest tertiles, 5.276±0.018 mmol/L; P=0.001). Reversely, FPG levels increased from lowest tertiles to highest tertiles of LDL-C, TC, and TG. we found that women in the first tertile with lower HDL-C level had a 1.75-fold increase in risk of IFG compared with non-diabetic women in the third tertile with higher HDL-C level (OR: 1.75; 95% CI: 1.20--2.56). In men, no significant association was found. We took age, BMI, waist/hip ratio, education, smoking, alcohol drinking, and physical exercise as adjusted variables. In Chinese non-diabetic women, dyslipidemia is independently associated with high levels of FPG; TG, HDL-C, and LDL-C are predictors of IFG independent of BMI and waist/hip ratio.
关键词: dyslipidemia plasma lipids plasma fasting glucose impaired fasting glucose non-diabetes
Vanadium metabolism investigation using substance flow and scenario analysis
Fangfang ZHANG, Huiquan LI, Bo CHEN, Xue GUAN, Yi ZHANG
《环境科学与工程前沿(英文)》 2014年 第8卷 第2期 页码 256-266 doi: 10.1007/s11783-013-0585-1
关键词: metabolism vanadium industry substance flow analysis scenario analysis
Insulin resistance and the metabolism of branched-chain amino acids
null
《医学前沿(英文)》 2013年 第7卷 第1期 页码 53-59 doi: 10.1007/s11684-013-0255-5
Insulin resistance (IR) is a key pathological feature of metabolic syndrome and subsequently causes serious health problems with an increased risk of several common metabolic disorders. IR related metabolic disturbance is not restricted to carbohydrates but impacts global metabolic network. Branched-chain amino acids (BCAAs), namely valine, leucine and isoleucine, are among the nine essential amino acids, accounting for 35% of the essential amino acids in muscle proteins and 40% of the preformed amino acids required by mammals. The BCAAs are particularly responsive to the inhibitory insulin action on amino acid release by skeletal muscle and their metabolism is profoundly altered in insulin resistant conditions and/or insulin deficiency. Although increased circulating BCAA concentration in insulin resistant conditions has been noted for many years and BCAAs have been reported to be involved in the regulation of glucose homeostasis and body weight, it is only recently that BCAAs are found to be closely associated with IR. This review will focus on the recent findings on BCAAs from both epidemic and mechanistic studies.
关键词: branched-chain amino acids leucine isoleucine valine insulin resistance
Jingyue Zhang, Yawen Song, Qianqian Shi, Li Fu
《医学前沿(英文)》 2021年 第15卷 第5期 页码 649-656 doi: 10.1007/s11684-021-0830-0
标题 作者 时间 类型 操作
Abnormal glycosylated hemoglobin as a predictive factor for glucose metabolism disorders in antipsychotic
XU Leping, JI Juying, DUAN Yiyang, SHI Hui, ZHANG Bin, SHAO Yaqin, SUN Jian
期刊论文
The
Prayoga SURYADARMA, Yoshihiro OJIMA, Yuto FUKUDA, Naohiro AKAMATSU, Masahito TAYA
期刊论文
Decreasing complexity of glucose time series derived from continuous glucose monitoring is correlatedwith deteriorating glucose regulation
期刊论文
decorated with polypyrrole and nickel-cobalt layered double hydroxide for high-performance nonenzymatic glucose
期刊论文
Clinical laboratory features of Meigs’ syndrome: a retrospective study from 2009 to 2018
Wenwen Shang, Lei Wu, Rui Xu, Xian Chen, Shasha Yao, Peijun Huang, Fang Wang
期刊论文
Low-carbohydrate diets lead to greater weight loss and better glucose homeostasis than exercise: a randomized
期刊论文
Neuroprotective effects of Ginkgo biloba extract and Ginkgolide B against oxygen–glucose deprivation/reoxygenation and glucose injury in a new in vitro multicellular network model
null
期刊论文
Prognostic value of fasting glucose on the risk of heart failure and left ventricular systolic dysfunction
Hui Wang, Yang Zhang, Zhujun Shen, Ligang Fang, Zhenyu Liu, Shuyang Zhang
期刊论文
Gender differences in the relationship between plasma lipids and fasting plasma glucose in non-diabetic
null
期刊论文
Vanadium metabolism investigation using substance flow and scenario analysis
Fangfang ZHANG, Huiquan LI, Bo CHEN, Xue GUAN, Yi ZHANG
期刊论文